Hemolytic-uremic syndrome (HUS) often occurs after a gastrointestinal infection with E coli bacteria (Escherichia coli OH7). However, the condition has also been linked to other gastrointestinal infections, including shigella and salmonella.
Hemolytic-uremic syndrome (HUS) is an acute, fulminant disorder characterized by thrombocytopenia, microangiopathic hemolytic anemia, and acute kidney injury. HUS usually occurs in children following an infection, typically with Shiga toxin–producing bacteria (eg, Escherichia coli OH7), but may also occur in adults. Diagnosis requires demonstrating characteristic laboratory test abnormalities, including direct antiglobulin test–negative hemolytic anemia.
In adults, the hemolytic-uremic syndrome is a much more heterogeneous condition. The clinical syndrome can occur under various circumstances.